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Diclofenac: An Overview Diclofenac a widely used nonsteroidal anti-inflammatory drug (NSAID) designed to reduce inflammation and as a pain reliever. It is commonly prescribed to treat conditions such as arthritis, menstrual pain, migraines, and other ailments that lead to pain or inflammation. What is Diclofenac? Diclofenac is an NSAID that works by inhibiting the enzymes..